Blog

  1. January 30, 2024

    Ketamine ain’t esketamine

    Ketamine’s been in the news a lot as a potential treatment for depression, PTSD, and more. It’s not FDA-approved (yet), but its cousin esketamine is approved for treating some forms of depression.

    That gets confusing, especially among lay people who don’t realize how important those extra two letters are. (Consider how you’d feel if you landed in Kansas instead of Arkansas, especially during tornado season.)

    Luckily, the good folks at Medscape have a great overview of the differences between ketamine and esketamine, including how they’re delivered, what they’re approved for, and the issues popping up as clinics offer “treatment” that could be ineffective, dangerous, or somewhere in between.

    While ketamine and esketamine are chemically related, they are very distinct in terms of their chemical compositions, the FDA-approved indications, dosing, and administration, as well as the level of study and data

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  2. January 26, 2024

    Why is hormone testing important and what are the types of hormone tests available?

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  3. January 24, 2024

    Multivitamin goodness

    Multivitamins are good for the brain.
    Multivitamins are good for the brain.
    Multivitamins are good for the brain.

    That is, a third study has confirmed that multivitamins have “a statistically significant benefit” on older folks’ cognition and memory."

    This latest meta-analysis, done by Mass General Brigham researchers, went a step further than the previous studies; it included in-person assessments like cognitive tests (“Who was Fred Flintstone’s wife?”). With those previous studies, more than 5,000 participants were included, so it’s pretty conclusive evidence.

    [I]nvestigators observed a modest benefit for the multivitamin, compared to placebo, on global cognition over two years. There was a statistically significant benefit of multivitamin supplementation for change in episodic memory, but not in

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  4. January 16, 2024

    Testosterone pellets for male TRT

    The concept of testosterone replacement therapy (TRT) dates back to the early 1900s. Observations of behavioral changes in castrated roosters formed the foundation of what we know to be hypogonadism or “low T.” The concept of “treat like with like” spurred research and by the mid 1930s, testosterone synthesis began. (1)

    During the 1930s, we saw the initiation of TRT with testosterone propionate injections as well as subcutaneous testosterone pellets.(2) By the mid 1940s, researchers had identified multiple indicators of low testosterone including depression, failing memory, increased fatigability, and reduced libido. We now apply that early research, with improved understanding of physiology and the aging process, to successfully treat millions of men who experience the unwanted effects of low testosterone.

    For years, men were prescribed testosterone injections,

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