When formulating compounds for topical application to the face and neck, especially for acne rosacea and acne vulgaris patients, Innovation Compounding gives special attention to designing products that do not cause blockage to pores, or non-comedogenic.

The more comedogenic a substance, the more likely it is to form a comedo, or clogged hair follicle in the skin. Comedos occur when keratin and oil combine and block the follicle. Some additives and ingredients are more comedogenic than others, which can perpetuate the formation of blackheads (open comedones) or whiteheads (closed comedones).

Our Doctor of pharmacy team places a high priority on formulating skin products that use low-comedogenic ingredients to reduce the potential to exacerbate a case of acne or other skin eruption.

The following tables provide a list of various chemicals that are used as ingredients in creams, lotions, gels, and liquids intended for topical use and their comedogenic probability. The comedogenicity of each chemical listed was determined by studies performed on rabbit ears or human subjects using the chemical at a 10% concentration in Propylene Glycol.

Please keep in mind that chemicals listed as “moderate” or “high” may not necessarily cause acne on all skin types or when used in small concentrations on acne-prone skin.

Skin care comedogenicity chart 1

Skin care comedogenicity chart 2


To learn more about the skincare products we provide or the conditions that we treat, please review our Derm Therapeutic Line.

Fulton, JE. Comedogenicity and Irritancy of Commonly Used Ingredients in Skin Care Products. J Soc Cosmet Chem. 1989; 40:321-333 Comedogenic Effects of Cosmetic Raw Materials. BeautyMag Online website. Available at http://www.beautymagonline.com/pages/comedogenic_effects_of_cosmetic_.htm Accessed Feb 18, 2009

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